More than half of all heart attacks occur in people with normal/low cholesterol: https://www.sciencedaily.com/releas…/2017/…/170412105837.htm
And, despite the fact that white females have almost 50% higher incidence of high cholesterol than white males (https://www.cdc.gov/cholesterol/facts.htm) males are twice as likely to have a heart attack: https://www.health.harvard.edu/…/throughout-life-heart-atta…
From at least 1988-2010 Americans reduced their total cholesterol and LDL numbers: https://www.ncbi.nlm.nih.gov/m/pubmed/23073951/
Yet cardiovascular disease deaths have been on the rise ever since: https://www.mdmag.com/…/cardiovascular-disease-deaths-on-ri… .
In-depth analysis of heart disease risk and cholesterol has repeatedly failed to verify cholesterol as a cause. Contrary to expectation, every time massive datasets are examined, most of the interpretation points the opposite direction: https://www.nhs.uk/…/study-says-theres-no-link-between-cho…/
That’s right. Lowering cholesterol ought to raise risk of heart disease. This would actually make more sense with the known biology, since cholesterol plays a vital role in controlling cardiovascular inflammation (the actual cause of heart disease), is a building block in every single cell of the body, and it’s the precursor to make every hormone that keeps us alive and lets us enjoy life.
“But didn’t we find that lowering cholesterol lowers risk?”, you may ask. No. What we found is that people who are so scared to die that they take a statin may trend toward statistical risk reduction. That could be due to the fact that patients have accepted they are at risk and are concurrently taking OTHER steps to stop killing themselves with other lifestyle behavior changes. This is called sample bias or embedded causation. It may also have to do with the fact that statins are synthesized from fungus and exert antimicrobial properties similar to other antibiotics. Again, since most heart attacks occur in people with low or normal cholesterol, and since we know for a fact that plaque develops in unhealthy people even when they lower blood serum cholesterol, cholesterol is a red herring.
Heart disease IS rampant atherosclerotic plaque buildup. We understand it pretty well. Immune function and dysfunction play a strong role. The antimicrobial properties of statins, therefore, are more explanatory for any possible benefit they may appear to have than the cholesterol-reducing impact. Just like with other antibiotics, patients may experience lower infection rate/duration/severity, creating a net reduction in total damage. Thus, in turn, we might expect less rampant plaque buildup.
“But isn’t the atherosclerotic plaque made OF cholesterol?”, you may be thinking. In part. It’s also made OF calcium. Why aren’t we eliminating calcium? The damage to the blood vessel walls around the buildup is from white blood cells. Why aren’t we eliminating white blood cells? Plaque formation also results from cell leftovers. Why aren’t we getting rid of cell waste? In fact, this is the question on which you want to focus. There is a much more straight-forward correlation of heart disease for people who have persistent hypertension and diabetes or prediabetes. These people don’t clear the body of excesses, by definition. Ergo, accumulation (of lots of things, including plaque) results.
“Isn’t one type of cholesterol different than another?”, you might ask. Precisely. Moreover, levels in your blood fluctuate within a day, because you make different amounts based on many changing factors. But you know what doesn’t fluctuate a whole lot? The amount of cholesterol and fat which ISN’T in the blood and isn’t in your food.
Blood serum cholesterol and dietary fat intake represent an infinitesimally small percent of cholesterol and fats in the body. You could eliminate all cholesterol from the blood and there’d still be more inside that person than was removed. Every cell in the body is made from cholesterol. It’s everywhere. You could eliminate all fats from the diet and you’d still be confronted with the fact that the average American carries over 55lbs of excess stored fat. That’s over 25,000 grams. Eating 0 grams of fat versus 17 grams in your meal today won’t even be noticed by your body. There are tens of thousands of grams already inside you. Trying to reduce risk of plaque without dramatically reducing body mass is a fool’s errand.
The final cause of death for everyone is adrenal crisis. It doesn’t matter if they’re shot and bleed out, stroke out, or age and tire out. The last thing that happens at death is the body is so damaged and defeated that we can’t summon adrenal output to keep other systems working and other cells alive. What is the precursor for adrenal output? Cholesterol. What keeps cells alive? Cholesterol. Without cholesterol, life doesn’t exist.
That said, adrenal glands must increase output tenfold when we get an infection. So it may turn out that statins provide a net benefit, prolonging the life of adrenal health, in that their antimicrobial properties reduce infections. It’s a rather complicated cost-benefit evaluation, since statins also damage other organs.
Regardless, the pseudoscientific canard about cholesterol and dietary fat from the 1960s has to go away. People dangerously accumulate plaque from unmanaged health and stress. People don’t dangerously accumulate plaque because of cholesterol and its natural healthy role of being a building block of life. In fact, the causal arrow goes precisely in the opposite direction: IN ORDER TO ADDRESS THE DAMAGE, the body increases its production of cholesterol to try to manage the damage. When an unhealthy body fails to synthesize hormones from cholesterol, guess what: there will be more unused cholesterol present in the blood. When the same unhealthy body fails to clear cell waste and energy, guess what: more will be present in the blood. Reducing cholesterol isn’t the answer. Managing health is the answer, which, in turn, will result in lower blood serum cholesterol. But that’s entirely beside the point. We want to reduce the accumulation of plaque. We want to build a healthy body that can clear plaques and rebuild damaged vessels. We don’t simply want to reduce the production of life-saving hormones.
Pay attention. It’s not a coincidence that the exact same company (Pfizer) had the same best-selling cholesterol drug (Lipitor) the same years that it had the best-selling erectile-dysfunction drug (Viagra). We make testosterone and all of the steroidal hormones from cholesterol.
Remember, many people successfully achieved lower cholesterol only to find that they are the majority of heart attack victims. Low cholesterol will kill you.