I have to laugh. There are well-understood mechanisms in biology, chemistry, and biochemistry. For some reason, we await mouse studies, human studies, epidemiological or statistical evidence for these same well-understood mechanisms in order to begin to entertain accepting them. It’s sort of ludicrous. Heart disease is a good example. Atherosclerotic plaque is not made from saturated fat; but someone somewhere has published a paper trying to statistically link dietary fat to heart disease. There is no known or proposed mechanism in all of biology for the human body to take animal fats and turn them into heart disease. But man o man do we try to link the two, because we wouldn’t want to accept that the nonstop inflammatory cascades from grains and sugars play any role in an inflammatory condition like heart disease.
Likewise, the impact of oxidized polyunsaturated fatty acids is known. But, we wouldn’t want to give up our fried vegetable oils. So, we await mouse studies, human studies, and statistical and epidemiological evidence. Well... here it is: