Anti-Inflammatories Linked to Worse Osteoarthritis Progression:

According to yet another study:
https://newatlas.com/.../nsaid-anti-inflammatories.../

It can be difficult to balance productive pro-inflammatory cascades against anti-inflammatory cascades. Neither inflammation nor lack of inflammation is good or bad. They both must coexist in a give-and-take.

Lengthy periods of psychological distress or physical stress express too long of anti-inflammatory cascades. It’s well-documented that long bouts of either will damage people. We KNOW that lengthy exercise sessions RAISE risk of upper respiratory infections due to suppression of immune function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803113/.

That is, it’s TOO MUCH anti-inflammation. As such, chronic endurance exercisers can expect to have needlessly accelerated deterioration of long-term joint integrity and health prospects.

Again, this is why moderate or short duration exercise and intense strength training is superior to all other exercise modalities, and not by a small degree.
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For persistent long-term use of anti-inflammatory drugs, we expect excessive wearing down of tissue. These findings may be surprising to people unfamiliar with how cell repair works. But growth, building, rebuilding, recovery, and healing are all inflammatory functions in biology and human health. Repair is INFLAMMATORY.