Research in part supported by the NIH altered two metabolic factors which researchers expected to lengthen lifespan 130%, but instead found a 400-500% increase: https://mdibl.org/…/mdi-biological-scientists-identify-pat…/
Readers may scoff when they see that these test subjects are nematodes. But the same metabolic pathways do exist within humans with the same functions. And there’s good reason to believe alteration of insulin expression would lengthen human life a lot. If you’re not wantonly growing cancer cells and fat (insulin volatility and elevation), your health risks are dramatically lowered. There is a good reason to believe altering TOR expression would also be a massive improvement in lifespan. When we grow skeletal muscle (mTOR), likewise, we reduce risk of death by dramatic leaps and bounds. And now we have lab data that shows combining the two leads to a synergistic effect far in excess of expectation.
The combinant outcome can be approximated with timed fasting for insulin management (https://www.sciencedirect.com/…/artic…/pii/S1550413118302535 ) and heavy resistance training followed by specific nutrition for mTOR (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504043/).
Will it raise our average lifespan to 400-500 years old? Not likely. But the two combined will certainly alter your life expectancy and improve quality of life in a palpable way.