This Answer to Anti-Aging Was Unknown In Science Until 2008

The Myokine - scientifically unknown until 2008

Resistance training remodels the immune system and cardiac architecture. The anti-inflammatory/health benefit of developing strength and skeletal muscle is only beginning to be unraveled.
I've long-suspected that there is more to muscle and strength training than "burning calories." But the simpleton calories-in/calories-out descriptions are still proffered as explanations.

If calories explain all, how do I have 50 more pounds of muscle and 15 fewer pounds of bodyfat than I did when I was 17? Did I eat more than I burned to gain the muscle, or less than I burned to lose the fat?
Furthermore, why do I have less hip/IT-band/shin pain now at a heavier body weight than when I was 17 years old? I've consistently loaded all structures with more resistance in the past 5 years than when I was in persistent orthopedic pain.

The myokine explains it.
https://en.m.wikipedia.org/wiki/Myokine